Hydrosoluble 3-arylidene-2-oxindole derivatives as tyrosine kinase inhibitors
US5840745A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 25, 1996 |
| Grant date | Nov 24, 1998 |
| Priority date | — |
| Expiry date | Sep 25, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D209/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel hydrosoluble 3-arylidene-2-oxindole derivatives, having tyrosine kinase inhibitor activity, encompassed by general formula (I), wherein m is zero, 1 or 2; A is a bicyclic ring chosen from tetralin, naphthalene, quinoline and indole; R.sup.1 is hydrogen, C.sub.1 -C.sub.6 alkyl or C.sub.2 -C.sub.6 alkanoyl; one of R.sup.2 and R.sup.3 independently is hydrogen and the other is a substituent selected from: a C.sub.1 -C.sub.6 alkyl group substituted by 1, 2 or 3 hydroxy groups; --SO.sub.3 R.sup.4 in which R.sup.4 is hydrogen or C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by 1, 2 or 3 hydroxy groups; --SO.sub.2 NHR.sup.5 in which R.sup.5 is as R.sup.4 defined above or a --(CH.sub.2).sub.n --N(C.sub.1 -C.sub.6 alkyl).sub.2 group in which n is 2 or 3; --COOR.sup.6 in which R.sup.6 is C.sub.1 -C.sub.6 alkyl unsubstituted or substituted by phenyl or by 1, 2 or 3 hydroxy groups or phenyl; --CONHR.sup.7 in which R.sup.7 is hydrogen, phenyl or C.sub.1 -C.sub.6 alkyl substituted by 1, 2 or 3 hydroxy groups or by phenyl; --NHSO.sub.2 R.sup.8 in which R.sup.8 is C.sub.1 -C.sub.6 alkyl or phenyl unsubstituted or substituted by halogen or by C.sub.1 -C.sub.4 alkyl; --N(R.sup.9).sub.2, …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.