Alkylbenzoylguanidine derivatives

US5840761A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rolf Gericke · Seeheim-Jugenheim, DE
• Dieter Dorsch · Ober-Ramstadt, DE
• Manfred Baumgarth
• Klaus-Otto Minck · Ober-Ramstadt, DE
• Norbert Beier · Reinheim, DE

Key dates

• Filing date: Aug 30, 1995
• Grant date: Nov 24, 1998
• Expiry date: Aug 30, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C317/44
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Alkylbenzoylguanidines of the formula I ##STR1## in which A, R.sup.1, R.sup.2 and R.sup.3 have the given meanings, and their physiologically harmless salts exhibit antiarrhythmic properties and act as inhibitor of the cellular Na.sup.+ /H.sup.+ antiporter.