Method for the treatment of cardiac arrhythmias and shortening of action potential duration
US5840762A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 12, 1996 |
| Grant date | Nov 24, 1998 |
| Priority date | — |
| Expiry date | Jan 12, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/165
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to the use of zucapsaicin (cis-8-methly-N-vanillly-6-nonenamide), the cis-isomer of capsaicin, to treat myocardial disorders, including the prevention, suppression or reversal of an abnormal cardiac rhythm, such as ventricular tachycardia. In vitro, zucapsaicin exhibits electrophysiologic properties distinct from capsaicin. In contrast to capsaicin, zucapsaicin significantly shortens the action potential duration at a dose of 10.sup.-5 M and has no effect on the amplitude of Phase 1 of the action potential in normal Purkinje cells. Zucapsaicin also prevents the induction of ventricular tachycardia of focal Purkinje origin when given intravenously after coronary occlusion in a dog model of acute myocardial infarction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.