Extrusion and freeze-drying method for preparing particles containing an active ingredient
US5843347A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 4, 1997 |
| Grant date | Dec 1, 1998 |
| Priority date | — |
| Expiry date | Aug 4, 2017 |
Classification
- Technology area (CPC F)Mechanical Engineering; Lighting; Heating
- CPC primaryF25C1/00
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation of particles each comprising an excipient forming a matrix and at least one active ingredient uniformly distributed in the mass of said matrix, said process, which comprises the operations of extrusion and then lyophilization, being characterized in that it comprises the steps consisting of PA1 (1.) the preparation of a homogeneous mixture from PA2 (a) at least one active ingredient, PA2 (b) a physiologically acceptable hydrophilic excipient, and PA2 (c) water to give a pasty mixture with a viscosity below 1 Pa.s, measured at room temperature (15.degree.-20.degree. C.); PA1 (2.) the extrusion of the resulting homogeneous mixture and the cutting of the extrudate to give moist particles; PA1 (3.) the freezing of the resulting particles as they fall under gravity through a stream of inert gas at a temperature below 0.degree. C.; and PA1 (4.) the freeze drying of said particles.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.