Retroviral vectors for the treatment of tumors, and cell lines containing them
US5843432A · kind A · utility
5Cited by
1References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 11, 1995 |
| Grant date | Dec 1, 1998 |
| Priority date | — |
| Expiry date | Oct 11, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/13043
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to recombinant retroviral vectors, derived from Moloney MuLV, carrying a suicide gene susceptible of transforming an inactive substance into a toxic substance for cells going through a division process, said vectors being characterized by the presence in their structure of LTR sequences from variants of MuLV, and having the properties: (a) of not being inactivated during passage through the carcino-embryonic or line germinal cells of mice; (b) the expression of the suicide gene kills only the cells in the course of division.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.