Method of preventing and treating bacterial infection of sutures and prosthetic devices, and promoting ingress of leukocytes into tumor foci

US5843436A · kind A · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• John D. Loike · Elmont, US
• Samuel C. Silverstein · New York, US

Key dates

• Filing date: Apr 22, 1996
• Grant date: Dec 1, 1998
• Expiry date: Apr 22, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/1709
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

An agent capable of inhibiting signalling mediated by a .beta..sub.1 integrin cell surface receptor of leukocyte cells will treat a bacterial infection associated with a surface of a foreign body over and around which fibrin has been deposited, or a malignant tumor over and around which tenascin has been deposited. In addition, coating a foreign body with a fibrinolytic agent will prevent chronic bacterial infection associated with the surface of the foreign body. Furthermore, an agent capable of stimulating signalling mediated by a .beta..sub.1 integrin cell surface receptor of leukocyte cells will treat chronic inflammation.