Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate

US5843468A · kind A · utility

Assignee

• ALZA CORPORATION · US

Inventors

• Terry L. Burkoth · Palo Alto, US
• Lina T. Taskovich · Palo Alto, US
• Russell D. Beste · Burlington, US
• Robert M. Gale · Los Altos, US
• Eun Soo Lee · Redwood City, US
• Richard D. Hamlin · Newark, US
• Su ll Yum · Los Altos, US

Key dates

• Filing date: May 13, 1996
• Grant date: Dec 1, 1998
• Expiry date: May 13, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/22
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions, devices, and methods for transdermal administration of an active agent are disclosed using a novel dual permeation enhancer mixture comprising lauryl acetate and a monoglyceride, preferably glycerol monolaurate. The dual permeation enhancer mixture comprising lauryl acetate is a potent permeation enhancer and provides stable systems which are more readily characterized.