Methods for detection of acute promyelocytic leukemia (APL)
US5843642A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jul 21, 1993 |
| Grant date | Dec 1, 1998 |
| Priority date | — |
| Expiry date | Jul 21, 2013 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/813
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a method of diagnosing APL in a subject which comprises detecting in a sample from the subject either nucleic acid encoding an abnormal RAR-.alpha. receptor or an expressed protein encoded thereby. The present invention also provides methods of identifying a subject with APL who will or will not respond to treatment with a retinoid, as well as a subjects with APL who do not express a detectable t(15;17) translocation but will or will not respond to treatment with a retinoid. In addition, the present invention provides methods for monitoring the activity of APL and the process of treatment of APL. The present invention provides methods of identifying a subject with a neoplastic condition other than APL who will or will not respond to treatment with a retinoid as well as methods for monitoring the level of disease activity and progress and adequacy of treatment of a neoplastic condition. Lastly, the present invention provides a method for inhibiting the growth of a neoplastic cell.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.