Diphtheria toxin receptor-binding region

US5843711A · kind A · utility

Assignees

• The Regents of the University of California · US
• President and Fellows of Harvard College · US

Inventors

• R. John Collier · Wellesley, US
• David S. Eisenberg · Los Angeles, US
• Haian Fu · Brookline, US
• Seunghyon Choe · Calabasas, US

Key dates

• Filing date: Nov 2, 1995
• Grant date: Dec 1, 1998
• Expiry date: Nov 2, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention features a polypeptide consisting of amino acids 379-535 of diphtheria toxin, and portions thereof. This region, shown by X-ray crystallographic analysis to comprise the receptor binding domain of diphtheria toxin, is used as an immunogen and clinical therapeutic against diphtheria.