Cancer associated gene protein expressed therefrom and uses thereof
US5843737A · kind A · utility
Inventors
Key dates
| Filing date | Dec 30, 1994 |
| Grant date | Dec 1, 1998 |
| Priority date | — |
| Expiry date | Dec 30, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
We have now discovered that eukaryotes, including mammals, have a gene that encodes a multifunctional protein having helicase activity, DNA repair activity, p53 sequestering activity and oncogenetic transformation potential. Enhanced transcripts and expression of this gene in non-testicular cells have a high correlation to disease state in a number of cancers, such as colorectal carcinomas, hereditary cancers resulting from defects in DNA repair pathways, breast cancers, etc. Accordingly, discovering enhanced levels of transcript or gene product in non-testicular tissues can be diagnostic of a predisposition to cancer, and prognostic for a particular cancer.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.