Streptomyces microorganism useful for the preparation of (R)-baclofen from the racemic mixture
US5843765A · kind A · utility
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3References
15Claims
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Key dates
| Filing date | Jan 31, 1997 |
| Grant date | Dec 1, 1998 |
| Priority date | — |
| Expiry date | Jan 31, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/902
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention disclosed relates to the biological production of substantially isomerically pure (R)-baclofen and structurally related compounds, from the racemic mixture of (R)- and (S)-isomers thereof, and to the isolation of a Streptomyces microorganism from Nature which is capable of preferentially metabolizing one of the isomers while showing minimal metabolic activity on the other isomer. A fermentation or bioconversion process using this microorganism or the cell-free enzymes derived therefrom for the biological resolution of a racemic mixture of (R)- and (S)-baclofen and structurally related compounds is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.