Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth
US5843925A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Dec 13, 1994 |
| Grant date | Dec 1, 1998 |
| Priority date | — |
| Expiry date | Dec 13, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/65
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a method for inhibiting angiogenesis and proliferation of endothelial cells by administering an inhibitory amount of a 7-substituted amino!-9-(substituted glycyl)amido!-6-demethyl-6-deoxytetracycline of Formula I: ##STR1## wherein R, R.sub.2, R.sub.3, and W are as defined in the specification. The invention also relates to a method for inhibiting proliferation of tumor cells and tumor growth by administering an inhibitory amount of a compound of Formula I in combination with a chemotherapeutic agent or radiation therapy. The invention also relates to compositions containing an effective inhibitory amount of a compound of Formula I in a pharmaceutically acceptable carrier.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.