Reagent including an osmium-containing redox mediator

US5846702A · kind A · utility

Assignee

• Boehringer Mannheim GmbH · DE

Inventors

• Zhi David Deng · Carmel, US
• Gerald Sigler · Carmel, US
• Nigel A. Surridge · Carmel, US
• Christopher D. Wilsey · Carmel, US
• Robert J. McEnroe · Royal Oak, US
• Walter Jernigan · Indianapolis, US
• Rebecca W. Muddiman · Indianapolis, US

Key dates

• Filing date: Dec 20, 1996
• Grant date: Dec 8, 1998
• Expiry date: Dec 20, 2016

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S435/817
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A new group of Os(II) and Os(III) compounds useful as redox mediators in electrochemical biosensors. These compounds have 1) low oxidation potential, 2) fast reaction kinetics between the electroactive center of an enzyme and the compound, 3) slow oxidation of osmium by oxygen, and 4) excellent solubility in aqueous medium. These mediators are particularly useful as a component of a reagent used in an electrochemical biosensor, wherein the biosensor is useful for measuring analytes from a biological fluid, such as blood.