Solid-supported membrane biosensors

US5846814A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Hans-Joachim Galla · Munster, DE
• Claudia Steinem · Munster, DE
• Karsten Reihs · Cologne, DE

Key dates

• Filing date: Feb 20, 1997
• Grant date: Dec 8, 1998
• Expiry date: Feb 20, 2017

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10S436/806
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

The new membrane biosensors consist of a solid A as a support, a lipid bilayer B as a membrane, spacers C incorporated between A and B and a receptor D embedded in the lipid bilayer. The new membrane biosensors are characterized in particular by their spacer C, which consists of a molecule of ethanolamine which forms an ester bond to the phosphatide group of the lipid bilayer B, an oligopeptide in helical or pleated sheet structure formed from 4-20 C.sub.2 -C.sub.10 -.alpha.-amino acids and a reactive group which enters into a chemical or physicochemical bond with the support A.