Inhibitors of rotamase enzyme activity

US5846981A · kind A · utility

Assignees

• GPI Nil Holdings Inc. · US
• The Johns Hopkins University School of Medicine · US

Inventors

• Joseph P. Steiner · Hampstead, US
• Solomon H. Snyder · Baltimore, US
• Gregory S. Hamilton · Catonsville, US
• Ted M. Dawson · Baltimore, US

Key dates

• Filing date: Jan 23, 1997
• Grant date: Dec 8, 1998
• Expiry date: Jan 23, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/185
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to the method of using neurotrophic pipecolic acid derivative compounds having an affinity for FKBP-type immunophilins as inhibitors of the enzyme activity associated with immunophilin proteins, and particularly inhibitors of peptidyl-prolyl isomerase or rotamase enzyme activity to stimulate or promote neuronal growth or regeneration.