Compositions and methods for buccal delivery of pharmaceutical agents
US5849322A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Oct 23, 1995 |
| Grant date | Dec 15, 1998 |
| Priority date | — |
| Expiry date | Oct 23, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/2086
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition for transmucosally administering a drug to the oral cavity comprises an adhesive layer comprising a hydrophilic polymer having one surface adapted to contact a first tissue of the oral cavity and adhere thereto when wet and an opposing surface in contact with and adhering to an adjacent drug-containing layer comprising an effective amount of a drug and optionally an effective amount of a permeation enhancer, wherein the drug-containing layer is adapted to contact and be in drug transfer relationship with a mucosal tissue of the oral cavity when the adhesive layer contacts and adheres to the first tissue. Preferred drugs include peptides, such as glucagon-like insulinotropic peptides. A method of transmucosally administering a drug to the oral cavity is also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.