Cyclic peptides containing Arg-Gly-Asp, and derivatives thereof, as adhesion inhibitors

US5849692A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Alfred Jonczyk · Darmstadt, DE
• Gunter Holzemann · Seeheim-Jugenheim, DE
• Brunhilde Felding-Habermann · Village of La Jolla, US
• Friedrich Rippmann · Heidelberg, DE
• Beate Diefenbach · Darmstadt, DE
• Horst Kessler · Schwalbach, DE
• Roland Haubner · Garching bei München, DE
• Jochen Wermuth · Garching bei München, DE

Key dates

• Filing date: Mar 15, 1996
• Grant date: Dec 15, 1998
• Expiry date: Mar 15, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K38/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to novel cyclopeptides of the formula I EQU cyclo-(Arg-B-Asp-D-E) I in which B, D, and E have the meanings defined herein, and their salts. These compounds act as integrin inhibitors and can be used, in particular, for the prophylaxis and treatment of disorders of the circulation and in tumor therapy.