Ortho-substituted benzoil acid derivatives

US5849796A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Rolf Gericke · Seeheim-Jugenheim, DE
• Dieter Dorsch · Ober-Ramstadt, DE
• Manfred Baumgarth
• Klaus-Otto Minck · Ober-Ramstadt, DE
• Norbert Beier · Reinheim, DE

Key dates

• Filing date: Aug 28, 1995
• Grant date: Dec 15, 1998
• Expiry date: Aug 28, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C317/46
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Ortho-substituted benzoic acid derivatives of the formula I ##STR1## in which R.sup.1, R.sup.2 and R.sup.3 have the given meanings, and Q is guanidyl, and also their physiologically harmless salts, exhibit antiarrhythmic properties and act as inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter. In addition, the compounds of the formula I, in which R.sup.1 to R.sup.3 and also Q have the given meanings, are suitable for use as valuable intermediates for the preparation of medicaments, in particular of inhibitors of the cellular Na.sup.+ /H.sup.+ antiporter.