Biologically active phosphotriester-type nucleosides and methods for preparing same
US5849905A · kind A · utility
16Cited by
2References
16Claims
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Key dates
| Filing date | Sep 13, 1996 |
| Grant date | Dec 15, 1998 |
| Priority date | — |
| Expiry date | Sep 13, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H21/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Compounds of formula RS--P(.dbd.O) (QR)--Nu where: R is a radical --(CH.sub.2)n-W--X; X is a radical --C(.dbd.Z) (Y) or --S--U; Z is O or S; W is O or S; Q is O or S; Y and U are an alkyl, aryl or saccharide radical which is optionally substituted with, for example, an OH, SH or NH group; n is equal to 1 to 4, preferably 1 or 2; and Nu is a radical consisting of a residue of a biologically active compound or the dephosphorylated residue of a compound which is biologically active when it bears a phosphate or phosphonate group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.