Fused benzeneoxyacetic acid derivatives which have PGI.sub.2 receptor anonist activity
US5849919A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Sep 27, 1996 |
| Grant date | Dec 15, 1998 |
| Priority date | — |
| Expiry date | Sep 27, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D401/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A fused benzeneoxyacetic acid derivative of the formula (I): ##STR1## wherein D is a 3-5-membered ring; B is a C.sub.1-4 group; R.sup.1 is OH alkoxy, (alkyl) amino, residue of an amino acid; A is phenyl, alkyl substituted by phenyl, residue of an imidazole, imidazole-2-yloxy(thio), 2-oxoimidazole, pyrazole, oxadiazole, oxazole, trizole, isoxazole or isothiazole, in the group of benzene may be substituted by one to three of alkyl, alkoxy, halogen, nitro or trihalomethyl; and salts thereof possess an agonistic effect on the PGI.sub.2 receptor, so is useful for prevention and/or treatment of thrombosis, arteriosclerosis, ischemic heart diseases, gastric ulcer and hypertension.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.