Method for the synthesis of bis-tetrahydrofuranyl annonaceous acetogenins
US5849936A · kind A · utility
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Key dates
| Filing date | Jul 25, 1996 |
| Grant date | Dec 15, 1998 |
| Priority date | — |
| Expiry date | Jul 25, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D307/58
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for the synthesis of bis-tetrahydrofranyl Annonaceous acetogenins, including the natural products and analogs thereof, is provided which proceeds by the Pd-mediated coupling of a bis-tetrahydrofuranyl-subunit comprising a terminal alkyne, with a (C4)-hydroxybutenolide subunit comprising a terminal vinyl iodide, followed by selective reduction of the resulting enyne.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.