Preparation of glycine-N,N-diacetic acid derivatives

US5849950A · kind A · utility

Assignee

• BASF SE

Inventors

• Thomas Greindl · Bad Dürkheim, DE
• Alfred Oftring · Bad Dürkheim, DE
• Gerold Braun · Ludwigshafen, DE
• Jochen Wild · Ruppertsberg, DE
• Birgit Potthoff-Karl · Weinheim, DE
• Georg Schuh · Ludwigshafen, DE

Key dates

• Filing date: May 24, 1996
• Grant date: Dec 15, 1998
• Expiry date: May 24, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C227/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Glycine-N,N-diacetic acid derivatives I ##STR1## where R is unsubstituted or substituted alkyl, alkenyl, alkoxylate groups, phenylalkyl, phenyl, a heterocyclic ring or a radical of the formula ##STR2## where A is an alkylene bridge or a chemical bond, and M is hydrogen, alkali metal, alkaline earth metal, ammonium or substituted ammonium in the appropriate stoichiometric amounts, are prepared by reacting PA1 A) corresponding 2-substituted glycines or 2-substituted glycinonitriles or doubled glycines of the formula ##STR3## or doubled glycinonitriles of the formula ##STR4## or precursors of the glycine derivatives named as starting material with formaldehyde and hydrogen cyanide in aqueous medium at a pH of from 0 to 11 or PA1 B) iminodiacetonitrile or iminodiacetic acid with appropriate monoaldehydes of the formula R--CHO or dialdehydes of the formula OHC--A--CHO and hydrogen cyanide in aqueous medium at a pH of from 0 to 11 and, where appropriate, subsequent hydrolysis of nitrile functionalities which are present, where the starting material used comprises unpurified raw material derived from the industrial synthesis of glycine derivatives or their precursors or of iminodiacetonit…