Human monoclonal anti-rhesus (D) antibodies and cell lines producing same

US5851524A · kind A · utility

Assignees

• Association pour l'Essor de la Transfusion Sanguine dans la Region du Nord · FR
• Biotest Pharma GmbH · DE

Inventors

• Roland Beliard · Santes, FR
• Ulf Bethke · Babenhausen, DE
• Dominique Bourel · La Madeleine, FR
• Ahmed Bouzidi · Annœullin, FR
• Herve Broly · Vevey, CH
• Peter Byrne · Alsbach, DE
• Magali Holuigue · Samer, FR
• Michael Kloft · Weiterstadt, DE
• Detlef Rohm · Darmstadt, DE

Key dates

• Filing date: Feb 10, 1997
• Grant date: Dec 22, 1998
• Expiry date: Feb 10, 2017

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/732
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to 2 human monoclonal antibodies of sub-classes IgG1 and IgG3, against the Rhesus D antigen and to a pharmaceutical composition containing a mixture of the said antibodies, more particularly intended for the prophylaxis of the haemolytic disease of the newborn. The invention also relates to the heterohybridoma cell lines that produce these antibodies, which are filed with the "Deutsche Sammlung von Mikroorganismen und Zellkulturen" under accession numbers DSM AC 2039 and DSM AC 2040.