Method of intracellular binding of target molecules
US5851829A · kind A · utility
92Cited by
0References
62Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 30, 1995 |
| Grant date | Dec 22, 1998 |
| Priority date | — |
| Expiry date | Mar 30, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/1063
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to a method by which one can target an undesired target molecule or target antigen, preferably a protein. The method comprises the intracellular expression of an antibody capable of binding to the target. A DNA sequence is delivered to a cell, the DNA sequence contains a sufficient number of nucleotides coding for the portion of an antibody capable of binding to the target operably linked to a promoter that will permit expression of the antibody in the cell(s) of interest. The antibody is then expressed intracellularly and binds to the target, thereby disrupting the target from its normal actions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.