Substituted 2-carboxyalkyl-3(fluorophenyl)-8-(3-halopropen-2-yl) nortropanes and their use as imaging agents for neurodegenerative disorders

US5853696A · kind A · utility

Assignees

• Organix, Inc. · US
• The General Hospital Corporation · US
• President and Fellows of Harvard College · US
• Northwestern University · US

Inventors

• David R. Elmaleh · Newton, US
• Bertha K. Madras · Newton, US
• Peter Meltzer · Lexington, US
• Robert N. Hanson · Newton, US

Key dates

• Filing date: Feb 20, 1996
• Grant date: Dec 29, 1998
• Expiry date: Feb 20, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2123/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are certain cocaine analogs useful for imaging of cocaine receptors and dopamine receptors. Also disclosed are analogs useful for imaging diagnostics for Parkinson's disease.