Glycoprotein L and clycoprotein M from kaposi's sarcoma associated herpesvirus, DNA encoding same and uses thereof

US5853734A · kind A · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Yuan Chang · New York, US
• Roy A. Bohenzky · Mountain View, US
• James J. Russo · New York, US
• Isidore S. Edelman · New York, US
• Patrick S. Moore · New York, US

Key dates

• Filing date: Nov 13, 1996
• Grant date: Dec 29, 1998
• Expiry date: Nov 13, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2710/16422
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides an isolated nucleic acid molecule which encodes KSHV glycoprotein L (gL). This invention provides an isolated nucleic acid molecule which encodes KSHV glycoprotein M (gM). This invention provides isolated gL and gM polypeptides. This invention provides antibodies specific to the polypeptides. Antisense and triplex oligonucleotide molecules are also provided. This invention provides a vaccine for Kaposi's Sarcoma (KS). This invention provides methods of vaccination, prophylaxis, diagnosis and treatment of a subject with KS and of detecting expression of a DNA virus associated with Kaposi's sarcoma in a cell.