Cell-specific gene therapy using as promoter novel promoters for tissue inhibitors of metalloproteinase-3

US5854019A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Hans-Harald Sedlacek · Marburg, DE
• Marisa Wick · Ilsenburg, DE
• Rolf Muller · Marburg, DE

Key dates

• Filing date: Jul 12, 1996
• Grant date: Dec 29, 1998
• Expiry date: Jul 12, 2016

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2830/008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to promoter sequences for a gene comprising a tissue inhibitor of metalloproteinase-3 (TIMP-3). This inhibitor is found in particular in macrophages, synovial cells, and connective tissue cells. The invention also relates to cell-specific gene therapy of a subject, wherein expression of a gene in a tissue is regulated by the aforementioned promoter sequence operationally coupled to said gene. The promoter may also be used in diagnostic methods.