Process for producing trans-4-hydroxy-L-proline
US5854040A · kind A · utility
12Cited by
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4Claims
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Key dates
| Filing date | Sep 9, 1996 |
| Grant date | Dec 29, 1998 |
| Priority date | — |
| Expiry date | Sep 9, 2016 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y114/11002
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Isolated and purified L-proline-4-hydroxylase which catalyzes hydroxylation of L-proline at the 4-position of L-proline in the presence of 2-ketoglutaric acid and a divalent iron ion to produce trans-4-hydroxy-L-proline. The L-proline-4-hydroxylase may be isolated from a microorganism selected from the group consisting of Dactylosporanlium sp. RHI deposited with the National Institute of Bioscience and Human-Technology Agency of Industrial Science and Technology, Japan, under the designation PERM BP-4400 and Amycolatopsis sp. RH2 deposited as FERM BP-4581.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.