MEKK-related signal transduction kinases
US5854043A · kind A · utility
Assignee
Inventor
Key dates
| Filing date | Oct 14, 1994 |
| Grant date | Dec 29, 1998 |
| Priority date | — |
| Expiry date | Oct 14, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to isolated MEKK proteins, nucleic acid molecules having sequences that encode such proteins, and antibodies raised against such proteins. The present invention also includes methods to use such proteins to regulate signal transduction in a cell. The present invention also includes therapeutic compositions comprising such proteins or nucleic acid molecules that encode such proteins and their use to treat animals having medical disorders including cancer, inflammation, neurological disorders, autoimmune diseases, allergic reactions, and hormone-related diseases. When MEKK is expressed, it phosphorylates and activates MEKs including MEK-1, MEK-2 and JEK.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.