Plasmin-resistant streptokinase
US5854049A · kind A · utility
10Cited by
3References
8Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Jun 9, 1995 |
| Grant date | Dec 29, 1998 |
| Priority date | — |
| Expiry date | Jun 9, 2015 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention features modified streptokinase (SK) molecules which are resistant to plasmin cleavage including a recombinant fusion protein in which the amino terminus of SK was blocked with a peptide, a recombinant fusion protein in which an amino-terminal deleted SK was blocked with a peptide, and a mutated SK in which plasmin-cleavage sites were altered to render those sites resistant to enzymatic cleavage.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.