Stable expression of human A.sub.2B adenosine receptors, and assays employing the same
US5854081A · kind A · utility
40Cited by
4References
7Claims
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Key dates
| Filing date | Jun 20, 1996 |
| Grant date | Dec 29, 1998 |
| Priority date | — |
| Expiry date | Jun 20, 2016 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/566
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Stable over-expression of native and hexahistidine/FLAG extended recombinant human adenosine receptors permits recovery of membranes and membrane fragments bearing a high density of adenosine receptors. Cell lines expressing all four sub-types of human adenosine receptors have been identified. The receptors, and membranes and membrane fragments bearing the same, can be used in assays to screen compounds for binding ability to the adenosine receptors, such as potential pharmaceutical agents.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.