Stimulating the differentiation of preadipocytic cells and therapies based thereon
US5854292A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Jan 22, 1997 |
| Grant date | Dec 29, 1998 |
| Priority date | — |
| Expiry date | Jan 22, 2017 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The differentiation of preadipocytic cells into adipocytic cells, in particular for correcting insulin-resistance disease states in mammalian organisms, notably in humans, for example type II diabetes and cardiovascular disorders such as hypertension and atherosclerosis, is stimulated by treating such preadipocytic cells, or a patient in need of such treatment, with an effective amount of (a) at least one ligand displaying affinity for the nuclear receptors for retinoic acid and/or isomers thereof, preferably at least one ligand displaying a specific affinity for the RAR receptors and even more preferably the RAR-.alpha. receptor and (b) at least one fatty acid, e.g., a polyunsaturated fatty acid.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.