Methods for treating the vasculature of solid tumors
US5855866A · kind A · utility
256Cited by
10References
26Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 2, 1994 |
| Grant date | Jan 5, 1999 |
| Priority date | — |
| Expiry date | Mar 2, 2014 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/55
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to methods and compositions for targeting the vasculature of solid tumors using immunologically-based reagents. In particular aspects, antibodies carrying diagnostic or therapeutic agents are targeted to the vasculature of solid tumor masses through recognition of tumor vasculature-associated antigens, such as, for example, through endoglin binding, or through the specific induction of endothelial cell surface antigens on vascular endothelial cells in solid tumors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.