Isolation and production of catalytic antibodies using phage technology

US5855885A · kind A · utility

Inventors

• Rodger Smith · Jefferson, US
• John McCafferty · Babraham, GB
• David John Chiswell · Gerrards Cross, GB
• Michael J. Darsley · Rockville, US
• Kevin Fitzgerald · Brookline, US
• John Kenten · Gaithersburg, US
• Mark Martin · Bethesda, US
• Richard C. Titmas · Rockville, US
• Richard O. Williams · Potomac, US

Key dates

• Filing date: Jul 14, 1994
• Grant date: Jan 5, 1999
• Expiry date: Jul 14, 2014

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N9/0002
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Disclosed and claimed are methods for producing catalytic antibodies, including human catalytic antibodies, from bacteriophage. The methods require the cloning, selection, screening, and isolation of catalytic antibodies. Also disclosed and claimed are the products themselves, the catalytic antibodies, made from the phage technology. In addition, catalytic antibodies produced from the phage technology and useful in prodrug activation are disclosed and claimed. And finally, the invention also understands the production of catalytic antibodies to phosphonates.