Compound preparation for the treatment of hypogonadal men and men with hypophyseal diseases

US5855905A · kind A · utility

Assignee

• Jenapharm GmbH & Co. KG · DE

Inventors

• Michael Oettel · Jena, DE
• Siegfried Golbs · Leipzig, DE
• Michael Dittgen · Apolda, DE
• Carsten Timpe · Bad Birnbach, DE
• Thomas Graser · Erfurt, DE
• Doris Hubler · Jena, DE

Key dates

• Filing date: Apr 30, 1997
• Grant date: Jan 5, 1999
• Expiry date: Apr 30, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P5/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A compound preparation for the treatment of hypogonadal men and men with hypophyseal diseases. This invention relates to compound preparations containing biogenous or synthetic androgens and biogenous or synthetic estrogens that are used for the treatment of imbalances of the testosterone metabolism in old age, of hypogonadal men, and of men with hypophyseal diseases. These compound preparations are present in various galenic formulations such as ointments, gels, sprays, TTS systems, tablets, lozenges, capsules, and suppositories. These preparations are used to treat the fluctuations of the testosterone metabolism occurring in old age and with certain diseases such as hypophyseal diseases (adenoma), hypogonadism and/or metabolic syndrome, to maintain the balance between androgens and estrogens found in young and healthy men in ill and/or elderly men as well. The preparations for treating these imbalances are suitable for oral, parenteral, percutaneous, sublingual or rectal administration depending on their galenic form. Thus, unphysiological changes in steroid-converting enzymes such as aromatases and reductases are avoided, which considerably improves the outcome of the therapy.