Determination of antibody production against administered therapeutic glycoproteins, especially monoclonal antibodies
US5856106A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 1, 1995 |
| Grant date | Jan 5, 1999 |
| Priority date | — |
| Expiry date | Nov 1, 2015 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S435/962
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Disclosed are a composition and method for determining the levels of specific immune responsiveness to a glycoprotein in an individual being treated therewith by (i) contacting a body fluid sample obtained from the individual prior to glycoprotein treatment with glycoprotein that has been modified to have an oxidized carbohydrate portion; (ii) contacting a body fluid sample obtained from the individual subsequent to glycoprotein treatment with the glycoprotein that has been modified to have an oxidized carbohydrate portion; and (iii) observing the degree of difference in the specific immune response to the oxidized glycoprotein in the pre- and post-treatment samples.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.