Assay for identification therapeutic agents
US5856115A · kind A · utility
0Cited by
9References
4Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 14, 1994 |
| Grant date | Jan 5, 1999 |
| Priority date | — |
| Expiry date | Feb 14, 2014 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/522
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is disclosed a method for screening for inhibitors of cellular second messenger signaling regulated by lysophosphatidic acid acyl transferase (LPAAT) and phosphatidic acid phosphohydrolase (PAPH), which method comprises contacting target cells or appropriate subcullular elements under appropriate conditions of stimulation with a candidate drug and assessing the levels of the relevant subsets of phosphatidic acid (PA) and diacylglycerol (DAG) in the presence and absence of the candidate drug.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.