Two-part oral products and methods of using same to remineralize teeth
US5858333A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Aug 7, 1998 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | Aug 7, 2018 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2800/88
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A two-part oral product capable of remineralizing subsurface lesions and/or mineralizing exposed dentinal tubules in teeth is composed of cationic and anionic discrete parts. The cationic discrete part contains at least one water-soluble calcium salt and, preferably, at least one non-toxic, water-soluble salt of a divalent metal other than calcium, and a first pharmaceutically acceptable carrier. The anionic discrete part contains at least one water-soluble phosphate salt and, preferably, at least one water-soluble fluoride salt, and a second pharmaceutically carrier. Preferably, one of the carriers is an aqueous carrier and the other of the carriers is a non-aqueous carrier. The cationic and anionic parts are simultaneously released from the product upon mixing of the product with water and/or saliva to form the mixed aqueous solution. In this way, calcium ions released by the calcium salt and phosphate ions released by the phosphate salt are simultaneously delivered to the tooth surfaces by the solution. To effect subsurface remineralization and/or mineralization, the parts are mixed together to form the mixed aqueous solution, and the solution is then promptly applied to the tee…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.