Pharmaceutical nanosuspensions for medicament administration as systems with increased saturation solubility and rate of solution

US5858410A · kind A · utility

Assignee

• Medac Gesellschaft Für Klinische Spezialpraparate MBH · DE

Inventors

• Rainer Muller · Penzberg, DE
• Robert E. Becker · Springfield, US
• Bernd Kruss · Biberach an der Riß, DE
• Katrin Peters · Berlin, DE

Key dates

• Filing date: Jun 19, 1997
• Grant date: Jan 12, 1999
• Expiry date: Jun 19, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided is a drug carrier comprising particles of at least one pure active compound which is insoluble, only sparingly soluble or moderately soluble in water, aqueous media and/or organic solvents, wherein said active ingredient is solid at room temperature and has an average diameter, determined by photon correlation spectroscopy (PCS) of 10 nm to 1,000 nm, the proportion of particles larger than 5 .mu.m in the total population being less than 0.1% (number distribution determined with a Coulter counter), and, when introduced into water, aqueous media and/or organic solvents, the active compound has an increased saturation solubility and an increased rate of dissolution compared with powders of the active compound prepared using an ultrasonic probe, a ball mill or a pearl mill, the solid particles having been comminuted, without prior conversion into a melt, by using cavitation or shearing and impact forces with introduction of a high amount of energy.