Tumor-associated kazal inhibitor-like polypeptides and encoding polynucleotides
US5858710A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 6, 1996 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | Nov 6, 2016 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides a human tumor-associated Kazal inhibitor (TAKI) and polynucleotides which identify and encode TAKI. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TAKI and a method for producing TAKI. The invention also provides for agonists, antibodies, or antagonists specifically binding TAKI, and their use, in the prevention and treatment of intestinal diseases including cancer. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding TAKI for the treatment of diseases associated with the expression of TAKI. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding TAKI.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.