Delivery of nucleic acids
US5858743A · kind A · utility
3Cited by
1References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 9, 1997 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | Jun 9, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/851
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a recombinant viral particle for delivering a nucleic acid to mammalian cells, the particle comprising an MLV-env protein that binds to an MLV-env receptor expressed on the surface of a target cell so as to cause infection thereof, and a surface-exposed EGF that binds to an EGF receptor generally not expressed on the surface of the target cell, but expressed on non-target cells that also express the MLV-env receptor, such that binding of the viral particle to the EGF receptor via EGF inhibits infection of the non-target cell by the viral particle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.