Patent · US Expired

Retroviral vector hybrids and the use thereof for gene transfer

US5858744A · kind A · utility

14Cited by

0References

26Claims

0Family size

Assignee

Boehringer Mannheim GmbH · DE

Inventors

Christopher Baum · Mazomanie, US
Carol Stocking-Harbers · Hamburg, DE
Wolfram Ostertag · Hamburg, DE

Key dates

Filing date	Mar 7, 1997
Grant date	Jan 12, 1999
Priority date	—
Expiry date	Mar 7, 2017

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2740/13043
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Replication-defective retroviral vector hybrids which are characterized in that they contain a) the U5 region and/or tRNA primer binding site of MESV as the U5 region and/or tRNA primer binding site in the leader region and b) the U3 and R regions from a Friend murine leukaemia virus (F-MuLV) as the U3 and R regions in the 3'-LTR and which are particularly suitable for an effective gene transfer in haematopoietic stem cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.