Gels for encapsulation of biological materials

US5858746A · kind A · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Jeffrey A. Hubbell · Austin, US
• Chandrashekhar P. Pathak · Austin, US
• Amarpreet S. Sawhney · Lexington, US
• Neil P. Desai · Los Angeles, US
• Jennifer L. Hill · Austin, US
• Syed F. A. Hossainy · Fremont, US

Key dates

• Filing date: Jan 25, 1995
• Grant date: Jan 12, 1999
• Expiry date: Jan 25, 2015

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T428/2989
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Water soluble macromers are modified by addition of free radical polymerizable groups, such as those containing a carbon-carbon double or triple bond, which can be polymerized under mild conditions to encapsulate tissues, cells, or biologically active materials. The polymeric materials are particularly useful as tissue adhesives, coatings for tissue lumens including blood vessels, coatings for cells such as islets of Langerhans, coatings, plugs, supports or substrates for contact with biological materials such as the body, and as drug delivery devices for biologically active molecules.