Stabilized enzymes and detergent compositions
US5858757A · kind A · utility
35Cited by
5References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 11, 1993 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | Nov 11, 2013 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N9/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates to stabilized subtilisin proteases wherein one or more prolines is substituted for a native amino acid at stabilizing positions defined both by the range of the dihedral angles in the primary structure present at the substitution site and by selected characteristics of the protease secondary structure in the vicinity of the substitution site, to nucleotide sequences that encode the stabilized proteases, and to host organisms that contain the nucleotide sequences encoding the stabilized proteases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.