Expression of cloned genes in the lung by aerosol- and liposome-based delivery
US5858784A · kind A · utility
68Cited by
16References
14Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 5, 1992 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | Nov 5, 2012 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K39/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for producing a mammal capable of expressing an exogenously supplied gene in cells of the airway are disclaimed. Liposome-nucleic acid complexes are prepared then delivered via aerosol to the lung airway. The invention provides a direct method for transforming pulmonary cells as a means for treating disorders of the lung as for providing a means for delivering substances systematically following expression in the lung.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.