Pharmaceutical compositions comprising synthetic peptide copolymer for prevention of GVHD

US5858964A · kind A · utility

Assignees

• YEDA RESEARCH AND DEVELOPMENT CO. LTD. · IL
• Board of Trustees of the Leland Stanford Junior University · US

Inventors

• Rina Aharoni · Rehovot, IL
• Ruth Arnon · Rehovot, IL
• Nelson J. Chao · Menlo Park, US
• Paul G. Schlegel · St. Georgen, DE
• Michael Sela · Rehovot, IL
• Dvora Teitelbaum · Rehovot, IL

Key dates

• Filing date: Oct 6, 1995
• Grant date: Jan 12, 1999
• Expiry date: Oct 6, 2015

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08G69/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pharmaceutical compositions comprising as active ingredient a synthetic random copolymer of average molecular weight of about 4,000-12,000, preferably 6,000-8,000, said copolymer consisting of glutamic acid (Glu), lysine (Lys), alanine (Ala) and tyrosine (Tyr) residues in a relative molar ratio of 1.4-2.1 parts of Glu to 3.2-4.4 parts of Lys to 4.0-6.0 parts of Ala to 1.0 parts of Tyr (herein GLAT copolymers), can be used in a method for prevention and treatment of graft-versus-host disease in patients in the course of bone marrow and organ transplantation.