Methods for inhibiting interaction of human MDM2 and p53
US5858976A · kind A · utility
3Cited by
0References
5Claims
0Family size
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Key dates
| Filing date | Feb 14, 1997 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | Feb 14, 2017 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10S436/813
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A human gene has been discovered which is genetically altered in human tumor cells. The genetic alteration is gene amplification and leads to a corresponding increase in gene products. Detecting that the gene, designated hMDM2, has become amplified or detecting increased expression of gene products is diagnostic of tumorigenesis. Human MDM2 protein binds to human p53 and allows the cell to escape from p53-regulated growth.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.