E6AP antisense constructs and methods of use
US5858987A · kind A · utility
12Cited by
2References
83Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 5, 1995 |
| Grant date | Jan 12, 1999 |
| Priority date | — |
| Expiry date | May 5, 2015 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the discovery that antisense nucleic acids complimentary to an E6AP gene can be used to regulate cellular p53 levels. In general the invention features E6AP antisense constructs which, by inhibiting E6AP activity, can modulate cellular p53 levels in both p53+ transformed cells and in normal cells. The invention also provides methods for treating papillomavirus (PV) induced condition, methods for regulating cellular p53 levels and methods for regulating cellular proliferation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.