Salts of azelastine having improved solubility

US5859003A · kind A · utility

Assignee

• ASTA Pharma Aktiengesellschaft · DE

Inventors

• Helmut Hettche · Dietzenbach, DE
• Reinhard Muckenschnabel · Frankfurt, DE
• Gerhard Scheffler · Bielefeld, DE
• Ilona Fleischhauer · Offenbach, DE
• Wolfgang Morick · Frankfurt, DE

Key dates

• Filing date: Aug 2, 1996
• Grant date: Jan 12, 1999
• Expiry date: Aug 2, 2016

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P43/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to salts of azelastine having improved solubility in water. The salts of the present invention are prepared by reacting azelastine with acetic acid, gluconic acid, lactic acid or malic acid. A pharmaceutical composition may be prepared containing an azelastine salt and a pharmaceutically-acceptable carrier or diluent therefor. The pharmaceutical composition is useful in the treatment of allergies, asthma, inflammatory and psoriasis disorders and provides a cytoprotective effect.