Methods for protecting against cardiac ischemia by administering adenosine A.sub.2a receptor antagonists

US5859019A · kind A · utility

Assignees

• The Trustees of the University of Pennsylvania · US
• National Institutes of Health, Office of Technology Transfer · US

Inventors

• Bruce Liang · Avon, US
• Kenneth A. Jacobson · Silver Spring, US

Key dates

• Filing date: Mar 7, 1997
• Grant date: Jan 12, 1999
• Expiry date: Mar 7, 2017

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/522
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods for reducing or preventing ischemic damage of the heart are disclosed. A preferred embodiment of the invention comprises the administration of a specific A.sub.2a receptor antagonist, 8-(3-chlorostyryl) caffeine, to patients suffering from ischemic damage or at risk for the same.